3p13 region: a possible location of a tumor suppressor gene involved in uveal melanoma

涉及葡萄膜黑色素瘤肿瘤抑制基因的可能定位:3p13

1) To contribute to a better understanding of the role of chromosomal rearrangements in the tumorigenesis of uveal melanoma, we present a case in which a structural aberration of chromosome 3 could indicate the specific region in which an uveal melanoma tumor suppressor gene could be located.

为了有助于更好地理解染色体重组在葡萄膜黑色素瘤发生中的作用，本文报道一例葡萄膜黑色素瘤，提示其3号染色体结构变异，可能为其肿瘤抑制基因的特定区域。

2) We obtained a primary cell culture, characterized by cytogenetic study, through GTG- and CBG-banding techniques by using a mechanical dissection of a tumor sample obtained from an uveal melanoma.

利用机械分离葡萄膜黑色索瘤标本，通过GTG-与CBG-显带技术，作者获得原代细胞培养并作细胞遗传学研究。

3) Cytogenetic analysis performed in the primary cell culture highlighted the presence of a structural rearrangement involving chromosomes 3 and 22.

对原代细胞培养作细胞遗传学分析，高度显示3号与22号染色体存在结构重组现象。

4) A t(3; 22) (p13; p11) was observed as the only present clonal aberration.

t(3; 22)(p13;p11)移位是唯一存在的克隆畸变。

5) The 3p13 breakpoint involved in the aberration observed in our case could be essential in restricting the candidate region for the locus of an uveal melanoma tumor suppressor gene located on chromosome 3.

本例所见变异之相关 3p13断点可能在限制3号染色体内葡萄膜黑色素瘤肿瘤抑制基因位点选择区域中起基本的作用。

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