Polyploidization and losses of chromosomes 1, 2, 6, 10, 13, and 17 in three cases of chromophobe renal cell carcinomata

3例嫌色肾细胞瘤(CRCC)中1、2、6、10、13与17号染色体的多倍体化与丢失

1) Clonal chromosome aberrations identified after short-term culture are presented for three cases of chromophobe renal cell carcinomas (CRCC).

本文报道对3例CRCC经短期培养后，识别出克隆染色体变异。

2) All tumors revealed abnormal karyotypes with a varying proportion of polyploid tumor cells.

全部肿瘤例均显示出不同比率的多倍体肿瘤细胞的核型异常。

3) Common numerical abnormalities were combined losses of chromosomes 1, 2, 6, 10, 13, and 17.

常见染色体数量异常并伴有1、2、6、10、13与17号染色体丢失。

4) Clonal karyotypic evolution was demonstrated in one case in which several related clones could be identified.

1例还显示克隆核型演变，其中可识别出数个相关克隆。

5) An additional balanced translocation t(3; 14) (p24; q22) observed in this case proved to be of constitutional nature by cytogenetic analysis of normal kidney cells and peripheral blood lymphocytes.

在此例肿瘤中，又观察到平衡易位t(3;14) (p24;q22)，经对正常肾细胞与外周血淋巴细胞作细胞遗传分析，证实为结构特性。

6) These cytogenetic findings provide further evidence that chromophobe renal cell carcinomas are characterized by a highly specific combination of chromosomal losses most commonly including chromosomes 1, 2, 6, 10, 13, and 17.

这些细胞遗传学结果进一步提示，嫌色肾细胞瘤系一染色体丢失的高度特异综合表现，最常见于1、2、6、10、13与17号染色体。

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