Title:Tryptophan pyrolysis products, Trp-p-1 and Trp-P-2 induce apoptosis in primary cultured rat hepatocytes

标题：色氨酸的热解产物Trp-P-1与Trp-P-2诱导原代大鼠肝细胞细胞凋亡

Content/内容：

1) The cytotoxicity of heterocyclic amines, dietary carcinogens derived from cooked foods, to primary cultured rat hepatocytes was studied.

本文研究烹饪食物中饮食致癌物稠杂环胺类对原代大鼠肝细胞的细胞毒性。

2) A tryptophan pyrolysis product, 3-amino-1, 4-dimethyl-5H-pyrido[4,3-b] indole(Trp-P-1) was the most cytotoxic of 11 compounds tested.

色氨酸热解产物3-氨基-1，4-二甲基-5H-吡哆[4, 3-b]吲哚(Trp-P-1)在11种测试化合物中细胞毒性最强。

3) Trp-P-1 was found to induce apoptosis as measured by morphological changes in nuclear chromatin and internucleosomal DNA fragmentation.

发现Trp-P-1诱导细胞凋亡，表现为核染色质与核小体间DNA分裂的形态学改变。

4) 3-Amino-1-methyl-5H-pyrido/ 4, 3-b/ indole(Trp-P-2) showed a moderate apoptotic effect, and other compounds had a similar but weaker effect.

3-氨基-1-甲基-5H-吡哆[4,3-b]吲哚(Trp-P-2)显示中等细胞凋亡效应，其他化合物效应相似但较弱。

责任编辑：admin