Mesenchymal stem cells in osteobiology and applied bone regeneration
骨生物学中间充质干细胞及其在骨再生中的应用
Content:
1) Bone marrow contains a population of rаre progenitor cells capable of differentiating into bone, cartilage, muscle, tendon, and other connective tissues.
骨髓含有一组罕见的前体细胞,能分化成骨、软骨、肌肉、肌腱与其他结缔组织。
2) These cells, referred to as MSCs, can be purified and culture expanded from animals and humans.
这些称为MSC 的细胞可来自动物或人类,并可予以纯化与培养扩增。
3) This review summarizes recent experimentation focused on characterizing the cellular aspects of osteogenic differentiation, and exploration of the potential for using autologous stem cell therapy to augment bone repair and regeneration.
本综述总结了近期以骨原性分化细胞特征为重点的实验研究，探索用自身干细胞疗法增强骨修复与再生的可能性。
4) The authors have completed an array of preclinical studies showing the feasibility and efficacy of MSC based implants to heal large osseous defects.
作者全面介绍前期临床研究，显示MSC移植治疔大型骨缺陷的便利性与有效性。
5) After confirming that syngeneic rat MSCs could heal a critical size segmental defect in the femur, it was established that human MSCs form bone of considerable mechanical integrity when implanted in an osseous defect in an immunocompromised animal.
在肯定同基因大鼠MSC 能治愈股骨关键节段重大缺陷之后，现已确定人类MSC移植入免疫损伤动物中骨缺陷后形成的骨，具有较大的机械整体性。
6) Furthermore, bone repair studies in dogs verify that the technology is transferable to large animals, and that the application of this technology to patients at geographically remote sites is feasible.
还有，狗骨修复研究证实该技术可推广至大型动物，并且此技术应用于边远地区病人具有可行性。
7) These studies suggest that by combining MSCs with an appropriate delivery vehicle, it may be possible to offer patients new therapeutic options.
这些研究提示，通过适当的递送载体，MSC可给这类病人带来新的治疗方法。
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