Drugs causing fixed eruptions: a study of 450 cases
药物性固定疹450例调查
BАCKGROUND:
1) Drug eruptions are among the most common cutaneous disorders encountered by the dermatologist.
药物性皮疹是皮肤科医师最常遇见的皮肤病症之一。
2) Some drug eruptions, although trivial, may cause cosmetic embarrassment and fixed drug eruption (FDE) is one of them.
有些药物性皮疹虽然不严重，但有损于面容，而固定疹(FDE)则是其中之一。
3) The diagnostic hallmark is its recurrence at previousty affected sites.
诊断标准是皮疹反复发生在同一部位。
OBJECTIVE: We evaluated 450 FDE patients to determine thc causative drugs.
目标：作者评价450 例FDE患者以确定致病性药物。
RESULTS:
结果：
1) The ratio of men to women was 1:1.1.
男女比率为1:1.1。
2) The main presentation of FDE was circular hyperpigmented lesion.
FDE的主要表现为环形色素沉着损害。
3) Less commonly FDE presented as: nonpigmenting erythema, urticaria, dermatitis, periorbital or generalized hypermelanosis.
较少表现有：非色素性红斑、荨麻疹、皮炎、眶周或全身黑色素沉着过多。
4) Occasionally FDE mimicked lichen planus, erythema multiforme, Stevens -Johnson syndrome, paronychia, cheilitis, psoriasis, housewife's dermatitis, melasma, lichen planus actinicus, discoid lupus erythematosus, erythema annulare centrifugum, pemphigus vulgaris, chilblains, pityriasis rosca and vulval or perianal hypermelanosis.
极为少见的FDE类似扁平苔癣、多形红斑、Stevens - Johnson综合征、甲沟炎、唇炎、生皮癣、家庭主妇皮炎、黑斑病、光化性扁平苔癣、盘状红斑狼疮、离心性环形红斑、寻常性天疱疮、冻疮、玫瑰糠疹及女阴或肛周黑色素沉着。
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