Differential distribution of three members of a gene family encoding Iow voltage-activated (T-type) calcium channels
编码低压激活钙通道(T型)基因簇三个成分的分布鉴别
1) Low voltage-activated ( T-type) calcium currents are observed in many central and peripheral neurons and display distinct physiological and functional properties.
在许多中枢与周围神经元中，发现有低压激活钙通道流，并显示出独特的生理功能特性。
2) Using in situ hybridization, we have localized central and peripheral neryous system expression of three transcripts (alpha1 G alpha1 H, and alpha1 I) of the T- type calcium channel family (CaVT).
应用原位杂交技术，作者已定序T型钙通道簇3个转录本(a1G、a1H与a1I)在中枢与周围神经系统中的表达。
3) Each mRNA demonstrated a unique distribution and expression of the three genes was largely complementary.
每个mRNA呈现独特的分布，并且3个基因表达大多是互补的。
4) We found high levels of expression of these transcripts in regions associated with prominent T-type currents, including inferior olivary and thalamic relay neurons (which expressed alphal G), sensory ganglia, pituitary, and dentate gyrus granule neurons ( alpha1 H), and thalamic reticular neurons (alpha1 I and alpha1 H).
作者发现，这3个基因高度水平表达与T型钙通道流优势区域有关，这些区域包括下橄榄核与丘脑传递神经元(表达为a1G)，感觉神经节、垂体与齿状回颗粒神经元(,1H)，以及丘脑网状神经元(a1与a1H)。
5) Other regions of high expression included the Purkinje cell layer of the cerebellum, the bed nucleus of the stria terminalis, the claustrum (alpha1 G), the olfactory tubercles (alpha1 H and alpha1 I), and the subthalamic nucleus (alpha1 I
and alpha1 G).
其他高度表达区域包括小脑的Purkinye氏细胞层，终纹神经核床、带状核(a1G)、嗅结节(a1H与a1I)，以及丘脑下神经核(a1I与a1H)。
6) Some neurons expressed high levels of all three genes, including hippocampal pyramidal neurons and olfactory granule cells.
有些神经元呈3个基因高度表达，包括海马锥体神经元与嗅颗粒细胞。
7) Many brain regions showed a predominance of labeling for alpha1 G, including the amygdala, cerebral cortex, rostral hypothalamus, brainstem and spinal cord.
许多脑区呈a1G优势标记，包括杏仁核、大脑皮质、喙侧下丘脑、脑王及脊髓。
8) Exceptions included the basal ganglia, which showed more prominent labeling for alpha1 H and alpha1 I, and the olfactory bulb, the hippocampus, and the caudal hypothalamus, which showed more even levels of all three transcripts.
例外者包括基底神经节，显示a1H与a1I优势标记，而嗅球、海马、尾下丘脑显示3个基因均呈现更为平坦的水平。
9) Our results are consistent with the hypothesis that differential gene expression underlies pharmacological and physiological heterogeneity observed in neuronal T-type calcium currents, and they provide a molecular basis for the study of T-type channels in particular neurons.
本研究最终结果显示与假设相一致，即不同的基因表达产生神经元T型钙通道流中药物学与生理学表现的多样性，为研究特定神经元T型钙通道提供了分子学基础。
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