Title: Drugs causing fixed eruptions: a study of 450 cases
标题：药物性固定疹450例调查
BACKGROUND/背景：
1) Drug eruptions are among the most common cutaneous disorders encountered by the dermatologist.
药物性皮疹是皮肤科医师最常遇见的皮肤病症。
2) Some drug eruptions, although trivial, may cause cosmetic embarrassment and fixed drug eruption (FDE) is one of them.
有些药物性皮疹虽然不严重，但有损于面容，而固定疹(FDE)则是其中之一。
3) The diagnostic hallmark is its recurrence at previously affected sites.
诊断标准则是皮疹反复发生在同一部位。
OBJECTIVE: We evaluated 450 FDE patients to determine the causative drugs.
目标：作者评价450例FDE患者以确定致病性药物。
RESULTS/结果：
1) Cotrimoxazole was the most common causeof FDE.
复方新诺明是引起FDE 最常见的原因。
2)Other drugs incriminated were tetracycline, metamizole, phenylbutazone, paracetamol, acetylsalisylic acid, mefenamic acid, metronidazole, tinidazole, chlormezanone, amoxycillin, ampicillin, erythromycin, belladonna, griseofulvin, phenobarbitone, diclofenac sodium, indomethacin, ibuprofen, diflunisal, pyrantel pamoate, clindamycin, allopurinol, orphenadrine, and albendazole.
其他涉及的药物有四环素、安乃近、保泰松、扑热息痛、乙酰水杨酸、甲灭酸、灭滴灵、替硝唑、氯美扎酮、阿莫西林、红霉素、颠茄、灰黄霉素、氨羊青霉素、苯巴比妥、双氨酚酸钠、消炎痛、布洛芬、双氟尼酸、噻吩嘧啶、氯林可霉素、别嘌呤醇、邻甲苯海拉明以及肠虫清。
CONCLUSIONS/结论：
1) Cotrimoxazole was the most common cause of FDE, whereas FDE with diclofenac sodium, pyrantel pamoate, clindamycin, and albendazole were reported for the first time.
复方新诺明是引起FDE最常见的原因，而双氯酚酸钠、噻吩嘧啶、氯林可霉素、别嘌呤醇引起FDE则为首次报道。
2) FDE may have multiform presentations.
FDE表现形式多样。
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