Secretory pattern of GH, TSH, thyroid hormones, ẠCTH, cortisol, FSH, and LH in patients with fibromyalgia syndrome following systemic injection of the relevant hypothalamic-releasing hormones
子宫肌痛综合征(FMS)患者注射相关下丘脑释放激素后生长激素(GH)、促甲状腺激素(TSH)、甲状腺激素、促肾上腺皮质激素(ACTH)、皮质醇、促卵泡激素(FSH)、促黄体生成激素(LH)的血清类型
1) To study the hormonal perturbations in fibromyalgia syndrome (FMS) patients we injected sixteen -FMS patients and seventeen controls a cocktail of the hypothalamic releasing hormones: Corticotropin-releasing hormone(CRH), Thyrotropin- releasing hormone (TRH), Growth hormone-releasing hormone(GHRH), and Luteinizing hormone-releasing
hormone (LHRH) and observed the hormonal secretion pattern of the pituitary together with the hormones of the peripheral endocrine glands.
为了研究FMS 患者激素紊乱，作者对16名FMS 患者与17名对照者注射一组下丘脑释放激案:促肾上腺皮质激素释放激素(CRH)、促甲状腺释放激素(TRH)、生成邀索释放激素(GHRH)与黄体生成激素释放激素(LHRH)，并观察垂体及外周内分泌腺的激素分泌模式。
2) We found in FMS patients elevated basal values of ACTH and cortisol, Iowered basal values of insulinlike growth factor I(IGF-I) and of triiodothyronine (T3), elevated basal values of follicle-stimulating hormone (FSHD) and lowered basal values of estrogen.
作者发现，FMS患者的ACTH与皮质醇基值增加，胰岛素样生长因子I(IGF-I)与三碘甲腺原氨酸(T3)基值下降，促卵泡激素(FSH)基值增加，雌激素基值下降。
3) Following injection of the four releasing-hormones, we found in FMS patients an augmented response of АCTH, a blunted response of TSH, while the prolactin response was exaggerated.
注射4种释放激素后发现FMS患者的ACTH 反应增加，TSH反应迟钝，而催乳数素反应增强。
4) The effects of LHRH stimulation were investigated in six FMS patients and six controls and disclosed a significantly blunted response of LH in FMS.
对6名FMS 患者与6名对照者检查其LHRH 刺激效应，并揭示FMS 患者的LH反应明显迟钝。
5) We explain the deviations of hormonal secretion in FMS patients as being caused by chronic stress, which, after being perceived and processed by the central nervous system (CNS), activates hypothalamic CRH neurons.
作者认为，FMS 患者的激素分泌偏差主要是因为长期应激所致，其中由中枢神经系统感应调节，激活下丘脑CRH神经元。
6) CRH, on the one hand, activates the pituitary-adrenal axis, but also stimulates at the hypothalamic level somatostatin secretion which, in turn, causes inhibition of GH and TSH at the pituitary level.
另一方面，CRH激活垂体肾上腺轴，但也在下丘脑水平上刺激生长激索释放激索抑制因子的分泌，反过来，在垂体水平上抑制GH 与TSH。
7) The suppression of gonadal function may also be attributed to elevated CRH by its ability to inhibit hypothalamic LHRH release, although it could act also directly on the ovary by inhibiting FSH- stimulated estrogen production.
性腺功能抑制也可归因于CRH增高而抑制下丘脑LHRH 释放，然而它也可通过抑制FSH 刺激的雌激素产生而直接作用于卵巢。
8) We conclude that the observed pattern of hormonal deviations in FMS patients is a CNS adjustment to chronic pain and stress, constitutes a specific entity of FMS, and is primarily evoked by activated CRH neurons.
作者总结认为，所见FMS 患者激素变异，是CNS 对长期疼痛与应急的调节反应，形成FMS 患者的特殊病体，并主要是由活化CRH神经元所致。
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