Neuroendocrine carcinoma of the breast: a case report of pure type
单纯型乳房神经内分泌癌
1) The case of pure neuroendocrine carcinoma of the breast occurring in a 51-year-old female is described.
本文报道一名51岁女性患单纯型乳房神经内分泌癌。
2) The tumor located in the upper outer guadrant was a relatively well- circumscribed, uncapsulated, yellowish white, rubbery mass measuring 2.5 cm х 2.0 cm x 2.0 cm.
肿瘤位于乳房上外象限，边缘相对清楚、无包膜、呈淡黄白色、橡皮样肿块，2.5cm X 2.0cm X 2.0cm大小。
3) Microscopically, the tumor was characterized by solid nest, lobular, trabecular and insular arrangements of small to medium-sized cells with uniform round to oval hyperchromatic nuclei and pale to eosinophilic cytoplasm.
显微镜下，肿瘤特征为实心巢、叶状、小梁状，小中型细胞呈岛样排列，伴一致的圆形至卵圆形深染色细胞核以及灰色至嗜伊红细胞质。
4) It showed focal stromal invasion.
肿瘤显示灶性基质侵袭。
5) The stroma was fibrous and rich in vascularity.
基质呈纤维性，血管丰富。
6) The tumor cells were argyrophilic and positive for cytokeratin CAM5.2, Leu-7, neuron-specific enolase, and chromogranin A.
肿瘤细胞显嗜银性，细胞角蛋白 CAM5.2、Leu-7、神经元特异性烯醇酶与嗜铬粒蛋白A均呈阳性。
7) Electron microscopy showed neurosecretory granules.
电子显微镜显示有神经分泌颗粒。
8) The tumor was DNA diploid with a low S-phase fraction by flow cytometry.
流式细胞仪显示，肿瘤呈DNA双倍体S期低积分。
9) The axillary lymph nodes were negative for metastasis.
腋淋巴结转移阴性。
10) The patient was well and without disease 16 months after mastectomy.
乳房切除后16个月，病人情况良好，无病症。
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